The way drugs are used to treat obesity is changing quickly, so healthcare professionals need to keep up with the latest news. Before 2012, there weren’t many weight loss drugs that the FDA has approved. So, what is the strongest weight loss prescription pill?
There is no such option which is said to be the best strongest pill which works 100% for everyone. But, still there are many options which are widely used.
Phentermine, which is sold under the brand names Lomaira and Adipex-P, and orlistat, which is sold under the brand names Xenical and Alli, were the most common anti-obesity medications at the time. 
So if you want to know; what is the strongest weight loss prescription pill, here are some options you can try:
Phentermine (Adipex, Suprenza, Lomaira)
Phentermine is the oldest and most commonly prescribed weight loss drug in the US. It was first licensed for short-term use to help people lose weight, but current clinical recommendations now include it in longer-term treatment plans.
People who use phentermine may lose roughly 5% of their body weight on average. You can get it in several forms, such as 15 mg and 30 mg capsules and 18.75 mg and 37.5 mg tablets. Some side effects are headaches, feeling too excited, high blood pressure, trouble sleeping, a fast or irregular heartbeat, and shaking.
Suprenza, one of the brand names, has tartrazine, a color that can cause allergic responses in some people. Phentermine may interact with monoamine oxidase inhibitors (MAOIs), sympathomimetic medications, alcohol, adrenergic neuron-blocking medicines, and possibly some anesthetics. These interactions can happen while using the substances or within 14 days of stopping them.
Orlistat (Xenical And Alli)
Xenical is the brand name for orlistat medication, a prescription weight-loss drug that is taken by mouth with meals up to three times a day. Orlistat is not as extensively used as newer anti-obesity medicines, and it is not safe for children or teens to consume
It works by stopping some of the dietary fat from being absorbed in your digestive tract, which lowers the total number of calories consumed. Orlistat may also help keep the weight off once you lose it.
Clinical trials have showed that after one year, up to 55% of persons who took orlistat lost at least 5% of their body weight, and about 25% lost 10% or more. But the drug might cause gastrointestinal problems like greasy stools, gas, and frequent bowel movements, especially when taken with meals heavy in fat.
Alli is the brand name for a lower-dose, over-the-counter form of orlistat. It can help people lose a little weight on a low-fat, low-calorie diet, but not as much as the prescription-strength version.
Contrave
Contrave is a pill that helps you lose weight. It has two active chemicals, naltrexone and bupropion, in it. Over the first few weeks, the dose is slowly raised so that the body can get used to it. The usual maintenance dose is two tablets taken twice a day, once in the morning and once in the evening.
This combination works by affecting parts of the brain that control hunger and cravings, which helps to lower both hunger and the desire to eat too much. Clinical trials have demonstrated that over 40% of persons administered Contrave for one year experienced a minimum weight reduction of 5%, with more than 20% achieving a loss of 10% or greater.
Contrave may be especially helpful for people who have trouble with emotional eating because bupropion also influences mood and reward circuits while eating.
At this time, Contrave is solely sold under its brand name; there is no generic version presently. Adults can use it, but it is not safe for kids or teenagers.
Phentermine-Topiramate (Qsymia)
Qsymia is a mix of phentermine and topiramate that is meant to help people lose weight by making them less hungry and managing their appetites for food. When taken together, these two drugs work better than each one alone.
Topiramate is also used to stop migraines, thus this medicine may be especially good for adults who are both overweight and suffer migraines. Research shows that people who utilize it regularly might lose an average of 5 to 10% of their body weight.
If a patient is not losing at least 5% of their baseline weight after 12 weeks on the highest dose, the medicine should be slowly stopped because it is unlikely to help any further.
You just need to take Qsymia once a day, and it comes in these different strengths which are 3.75 mg/23 mg, 7.5 mg/46 mg, and 15 mg/92 mg.
Some common side effects are paresthesia (weird skin sensations), dizziness, a change in taste, trouble sleeping, diarrhea, and a dry mouth. People with uncontrollably high blood pressure, coronary artery disease, hyperthyroidism, glaucoma, or a known sensitivity to stimulants should not take this medicine.
Conclusion
Patients typically wish to know which anti-obesity drug is the best or most beneficial for them as the number of these drugs grows. It’s not easy to find the “strongest” weight reduction drug, though. Newer drugs aren’t necessarily better, and treatment needs to be tailored to each patient’s needs and medical history.
