Eli Lilly is one of the world’s leading pharmaceutical companies, well known for developing life-changing medicine. Over the years, the company has developed highly important treatments for areas like cancer treatment, diabetes management, and mental health. But now, Eli Lilly is making headlines in another field—weight loss therapy.
As obesity rates continue to rise worldwide, the company’s new weight-management drug has gained enormous attention. Patients, doctors, and even the general public are showing interest in how this medicine could transform the way we think about weight loss.
Eli Lilly Weight Loss Drugs
1. Zepbound (Tirzepatide)
Zepbound is a weight loss injection that has FDA approval. It has tirzepatide in it, which is a drug that works with your body’s hormones to control hunger and speed up your metabolism.
- This suggests that your feelings of fullness last longer.
- Cravings are reduced.
- Your body uses energy more efficiently.

This helps people eat less and use their energy more efficiently. A lot of people have had great results, with some losing more than 20% of their body weight when they eat well and work out regularly.
How Effective Is Zepbound for Weight Loss?
Clinical studies indicate that Zepbound is one of the best weight loss drugs available today. In fact, many patients have reported losing over 20% of their body weight when using Zepbound in combination with regular exercise and a healthy diet.
Zepbound is therefore a superior option to many of the more conventional weight loss techniques.
The benefits of Zepbound
People who took Zepbound along with a healthy diet and regular exercise reported losing more than 20% of their body weight in clinical trials. That’s a significant improvement over traditional diet methods.
Among the main benefits are:
- Reduced appetite and cravings
- Improved blood sugar control, especially for people with type 2 diabetes
- Decreased risk of conditions linked to obesity, such as heart disease and high blood pressure
- Significant weight loss that improves the quality of life
Possible Side Effects of Zepbound
Like all medications, Zepbound may have side effects. Some may require medical attention, but the majority are mild and manageable.
Common side effects include
- I feel nausea 25%
- Feeling queasy
- Constipation is reported by 17% of people.
- Loss of appetite
- Hair loss 5%
The following are serious but uncommon side effects:
- Severe stomach pain
- Pancreatitis symptoms (inflammation of the pancreas)
- Low blood sugar, especially in diabetics who are also taking other drugs
- Allergic reactions, including swelling or trouble breathing
If you experience any severe or ongoing side effects, you should contact your doctor immediately. Zepbound side effects (more detail)
How Do I Respond to an Overdose?
Seek emergency medical attention right away if you think you may have taken too much Zepbound. Overdose symptoms can include
- Extreme nausea and vomiting
- Feeling lightheaded or fainting
- Severe hypoglycemia, which manifests as sweating, trembling, and disorientation
For immediate assistance, dial your local emergency number (such as 911 in the US) or the Poison Help Line at 1-800-222-1222. Overdosing can be dangerous, so delays should be avoided.
2. Orforglipron (a drug being tested in the mouth)
Eli Lilly is currently testing orforglipron in clinical trials as a weight loss pill. Orforglipron comes in pill form, which is easier for people who don’t want to use needles than Zepbound, which is an injection.

Early research suggests that it may help people lose weight in a similar way, and if it gets the green light, it could be a new, easy option for patients in the near future.
How Does Orforglipron Work?
Orforglipron is part of a group of medicines called GLP-1 receptor agonists. These medicines work with your body’s natural hormones to:
- Reduce hunger
- Help you feel full faster
- Slow down digestion
- Improve blood sugar control
Because of this, people who take Orforglipron usually eat less and find it easier to lose weight.
Effects of Orforglipron
Studies show that Orforglipron has some very positive effects:
- On average, people taking it lost about 11–12% of their body weight.
- More than half of the patients lost at least 10% of their weight.
- It also helped lower blood pressure, cholesterol, and inflammation.
This means it may help with weight loss and improve overall health.
Side Effects of Orforglipron
Like most medicines, Orforglipron can cause side effects. Many of these are related to the stomach and are usually mild.
Common side effects include
- Nausea
- Stomach pain
- Vomiting (sometimes)
Some people also noticed a slightly higher heart rate. A few patients stopped taking it because the side effects were too strong.
What Should I Do in Case of an Overdose?
Serious side effects like severe nausea, vomiting, diarrhea, dehydration, or dizziness could result from taking too much forglipron. What to do is as follows:
- Immediately stop taking the medication.
- Go to the ER, poison control, or your doctor.
- Bring the pill bottle or information about the dosage.
- Consider drinking water to prevent dehydration.
In addition to monitoring your blood sugar and heart rate, doctors may administer IV fluids or medications to treat nausea.
Why Orforglipron is Different
The primary distinction is that Zepbound and other Eli Lilly weight loss medications are injections, whereas orforglipron is a pill.
This makes Orforglipron more convenient for many people. Even though injections may sometimes help people lose a little more weight, the pill could be more popular because it’s easier to take every day.
In conclusion
Advancements regarding Orforge and Zepbound greatly expand Eli Lilly’s weight loss. Unlike Zepbound, which is currently being studied as a daily tablet, Orforglipron is a convenient medicine that achieves 11-12% weight loss over 18 months and is in the testing phases.
People who prefer pills over injections are much more likely to opt for this medicine, or Orforglipron, as it is more convenient.
These dual advancements testify to Eli Lilly’s dedication to redefining the obesity epidemic with robust, clinically proven solutions that empower patients to attain sustainable weight loss and improved wellness.