Find out star athletes and celebrities who’ve taken glp-1 weight loss drugs and check what they have to share about their experiences on the revolutionary weight loss drugs.
Celebrities’ Comments on Taking GLP-1s
These celebrities are helping to normalize GLP-1s.
Hollywood’s “worst kept secret” now consists of GLP-1 medications. From award-winning actors to tennis legends, more and more famous people are describing how GLP-1 medicines such as Ozempic, Wegovy, Zepbound, and Mounjaro have helped their weight loss journeys.
Their honesty is changing the discussion from shame toward frankness about weight control and the influence this might have on all components of life, including both physical and mental health.
Fifteen well-known celebrities who’ve taken glp-1 weight loss drugs are listed here along with what worked, what didn’t, and how it transformed them.
Serena Williams
Using the GLP‑1 drug, the tennis great Serena Williams announced in summer 2025 that she shed 31 pounds (lb) after having her second child. Tirzepatide, Zepbound. In an interview with People, she stressed that she felt stuck even after a lot of sports practice and good food.
“I knew my body was missing something it needed.” Williams noted, “For me, the response was GLP-1s.”
Emphasizing that taking a weight loss medication “isn’t a shortcut,” Ro, a compensated ambassador for Ro, a telehealth GLP-1 supplier, is using her platform. It’s healthcare. And the medication is one component of a more extensive strategy that also involves a nutritious diet and exercise.
“I feel like I have a lot of energy, which is fantastic.” Williams said, “I just feel relatively decent about it.”
Oprah Winfrey
Winfrey discussed all things GLP-1 on An Oprah Special: Shame, Blame, and the Weight Loss Revolution, which she presented on ABC in March 2024.
“I never imagined in my whole life that we would be discussing drugs helping others like me who have battled.” She told about her years of being over-weight.
Winfrey began a discussion on why there is so much judgment around taking these as well as opened up about her own path. drugs aimed to bring their usage into line.
“Therefore I approach this conversation in the hope that we can begin letting go of the stigma, the shame, and the judgment to stop Winfrey remarked that shaming other people for being overweight or how they decided to lose and not to lose weight.“
Rebel Wilson
Pitch Perfect and The Hustle’s star said she took Ozempic for a while to keep the weight loss she had. When she made 2020 her “Year of Health” and shed 77 pounds.
She later noted in a 2024 interview, “Someone like me could have an infinite desire for sweets, therefore I think those medications might be good.” Wilson said she was content with her present “still curvy and solid” weight and had stopped using GLP-1s.
“I believe strongly that young women ought only look like themselves; they should not attempt to be Victoria’s Secret models. I She also declared, understand that my attitude with food is complex.”
Whoopi Goldberg
The actress and talk show host disclosed to her cohosts on The View in 2024 that she took Mounjaro (tirzepatide) to lose a lot of weight. weight. “I will tell you, I weighed practically 300 lb when I made [the 2022 movie] Till. I had taken all of those steroids,” I was on all this stuff, and the Mounjaro was one of the things that aided my weight reduction. That’s what I utilized.“
Goldberg also talked on how damaging all the ongoing conversation about people’s looks can be and how everyone should be kind to themselves and others. “Maybe the key is to stop judging everyone.” She said, “Maybe that’s the key.”
Charles Barkley
Besides following a nutritious diet and exercising, the ex-pro basketball player claimed Mounjaro helped him lose roughly 60 pounds.
Barkley said, according to a social media post, “It’s been fantastic; I’m starting to feel like a human being.” “It’s been amazing,” he said in describing his experience, and his ultimate aim is to live longer. He started at 352, and with a final objective of 270, he reported, “I’m down to 290.”
Kathy Bates
Over the last seven years, the Oscar winner Kathy Bates has shed 100 lb-80 from lifestyle tweaks and the remaining 20 with Ozempic. The mission started after a type 2 diabetes diagnosis motivated her to “get serious about her health,” as she described it in an interview with the magazine in 2024.
“It was so much work … especially during COVID,” said Bates.
The actress also revealed that she plans on exercising more with things like ‘walking around the house carrying my beautiful baby boy.
No, I’m not still 10 years old. I’ve been on a quest to become the healthiest, strongest version of myself for my kids and me. I’ve worked with a dietitian, made huge lifestyle changes, and started working out with a trainer, and yes, I employed science and support (shoutout to Mounjaro!) to assist me after my 2nd pregnancy. And I’m so happy I did because I feel great.”
Billie Jean King
Ten-time Grand Slam winner Billie Jean King spoke to actor Julia Louis-Dreyfus on the podcast Wiser Than Me about her decision to try a GLP-1.
“I’m a binge eater. “Every morning, I wake up, and I tell myself I have an eating disorder. It’s interesting with the new injections, you know, with the Ozempics of the world. It’s very interesting because my doctor wants me to try it.”
She later revealed that she had already started on the medication and hoped that it would help quiet the food noise in her mind.
Jim Gaffigan
The comedian Jim Gaffigan, author of the bestselling book Dad Is Fat, shared in an interview with People that after his weight reached 270 pounds, he tried Mounjaro and lost 50 pounds, crediting the drug for helping him feel better, lighter, and more alive. “I’m just grateful because it’s such a better life,” he said.
Gaffigan is puzzled by the stigma around the medication, which is part of the reason he wanted to talk about it. “I don’t think there’s anything wrong with it. It’s just whatever gets you through,” he said.
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Claudia Oshry
For Oshry, a comedian, the cohost of the podcast The Toast, and the creator of the popular Instagram account @girlwithnojob, taking a GLP-1 was a no-brainer. She told listeners on her podcast, “You thought they were going to make a weight loss drug and I wasn’t going to take it?”
She joked at the time that she would regain the weight because her Ozempic use wasn’t permanent. In a 2024 interview she revealed that she’d stopped taking the injections when she and her husband, Ben Soffer, decided to have kids.
Elon Musk
When one fan asked the billionaire owner of X in 2022, “What’s your secret? You look awesome, fit, ripped, and healthy. Lifting weights? Eating healthy?” Musk credited fasting and Wegovy for his transformation.
The Tesla and SpaceX chief has said he wants to make the drug more accessible to all Americans, that “nothing would do more to improve the health, lifespan, and quality of life for Americans” than making GLP-1s “super low cost to the public.”
Rosie O’Donnell
The actor and comedian first revealed on TikTok that she had shed 10 lb on Mounjaro and then followed it up with another post about how she lost 15 lb on the lowest dose.
Two years later, O’Donnell is still “shocked” by the transformation of her body. In addition to staying on the weight loss drugs, the actor eats less sugar, drinks water, and tries to move more.
Tracy Morgan
The comedian and former star of The Last O.G. made headlines when he shared on Today in 2023 that he was taking Ozempic. “That’s how this weight got lost. I went and got a prescription and I got Ozempic. I’m not letting it go,” he said.
Morgan has continued to praise the drug, saying, “Ozempic did great by me and I was glad to use it. I take Ozempic every Thursday. It cuts my appetite in half.”
Chelsea Handler
Surprisingly, the comedian didn’t know she was taking Ozempic when she first received a prescription, she said in an interview on the Call Her Daddy podcast. “My anti-aging doctor just hands it out to anybody,” Handler said. “I didn’t even know I was on it.”
Apparently, that doctor suggested she take it “if you ever want to drop five pounds.” Handler later realized she was on the medication when she told a friend she was taking semaglutide, and her friend said it was Ozempic. Since then, Handler has stopped taking the medication.
Amy Schumer
Schumer’s first go-round with a GLP-1 didn’t go well. On a 2023 episode of the talk show Watch What Happens Live With Andy Cohen, the comedian and actor said she was “one of those people that felt so sick” taking Ozempic, which led her to discontinue it.
Three years later, in 2025, the actor reported she was having “a really good experience” taking a different weight loss drug, Mounjaro, along with hormone replacement therapy for perimenopause symptoms.
The Takeaway
Celebrities who’ve taken glp-1 weight loss drugs includes Serena Williams and Charles Barkley as they have have spoken openly about GLP-1 medications in their weight loss journey
These stars describe both the benefits and challenges of Ozempic, Wegovy, Zepbound, and Mounjaro. Their stories show how GLP-1s can be transformative for some people but are not a permanent solution for others.
